hrp0086p1-p10 | Adrenal P1 | ESPE2016

Current Dilution Methods Cause Large Variations and Inaccuracies when Making up 1 μg Synacthen Dose

Cross Alexandra S , Sachdev Pooja , Wright Neil P , Jabbar Imran , Elder Charlotte J

Background: The low-dose short Synacthen test is a popular diagnostic test of adrenal insufficiency in children. It is employed by 82% of UK paediatric endocrinologists. Although various dosing strategies exist, 1 μg is most commonly employed, however none of the low-dose forms are commercially available. A BSPED survey revealed 14 different methods for diluting 250 μg/ml ampoules.Objective and hypotheses: Do various dilution strategies result ...

hrp0086p1-p753 | Pituitary and Neuroendocrinology P1 | ESPE2016

The Intra- and Inter-User Reliability of Testicular Volume Estimation – A Simulation Study

De Silva Shamani , Akbarian-Tefaghi Ladan , Langley Joseph , Stanton Andrew , Wright Neil P , Elder Charlotte J

Background: Measuring testicular volume (TV) by orchidometer is a standard method of pubertal staging in boys. A paucity of evidence exists as to its inter and intra-user reliability and the impact of clinicians’ gender, training and experience on the accuracy of measurements.Objective and hypotheses: We engineered prosthetic models of different size testes to investigate the reliability of TV estimation.Method: The study was ...